| 1. Round | 15/08/2021 | Bursaspor | - | Adanaspor | 1:1 | ||||
| 2. Round | 23/08/2021 | BB Erzurumspor | - | Bursaspor | 2:1 |  |
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| 4. Round | 12/09/2021 | Altınordu FK | - | Bursaspor | 2:1 |  |
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| 5. Round | 15/09/2021 | Bursaspor | - | Samsunspor | 4:1 | ||||
| 6. Round | 19/09/2021 | Tuzlaspor | - | Bursaspor | 0:0 | ||||
| 7. Round | 26/09/2021 | Bursaspor | - | MKE Ankaragücü | 0:4 | ||||
| 9. Round | 17/10/2021 | Bursaspor | - | Boluspor | 3:1 | ||||
| 10. Round | 24/10/2021 | Balıkesirspor | - | Bursaspor | 0:2 | ||||
| 11. Round | 01/11/2021 | Bursaspor | - | Keçiörengücü | 2:0 | ||||
| 12. Round | 07/11/2021 | Kocaelispor | - | Bursaspor | 2:1 | |
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| 14. Round | 26/11/2021 | Gençlerbirliği | - | Bursaspor | 2:0 | ||||
| 15. Round | 05/12/2021 | Denizlispor | - | Bursaspor | 1:3 | |
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| 16. Round | 11/12/2021 | Bursaspor | - | Manisa FK | 1:1 | ||||
| 17. Round | 16/12/2021 | Ümraniyespor | - | Bursaspor | 4:1 | ||||
| 20. Round | 08/01/2022 | Adanaspor | - | Bursaspor | 3:1 | ||||
| 21. Round | 16/01/2022 | Bursaspor | - | BB Erzurumspor | 0:0 |
Slovenia