1. Round | 23/08/1980 | Willem II | - | FC Twente | 0:2 | ||||
2. Round | 26/08/1980 | FC Twente | - | FC Utrecht | 3:0 | ||||
3. Round | 29/08/1980 | FC Twente | - | Go Ahead Eagles | 3:1 | ||||
4. Round | 02/09/1980 | Roda JC Kerkrade | - | FC Twente | 6:1 | ||||
9. Round | 18/10/1980 | FC Twente | - | FC Groningen | 3:1 | ||||
10. Round | 25/10/1980 | FC Den Haag | - | FC Twente | 1:0 | ||||
11. Round | 31/10/1980 | FC Twente | - | AZ '67 Alkmaar | 1:1 | ||||
13. Round | 21/11/1980 | FC Twente | - | SC NEC | 6:1 | ||||
12. Round | 24/11/1980 | PEC Zwolle | - | FC Twente | 0:0 | ||||
14. Round | 29/11/1980 | AFC Ajax | - | FC Twente | 5:3 | ||||
16. Round | 13/12/1980 | Sparta Rotterdam | - | FC Twente | 1:2 | ||||
15. Round | 16/12/1980 | FC Twente | - | MVV | 3:3 | ||||
17. Round | 20/12/1980 | Feyenoord | - | FC Twente | 1:0 | ||||
18. Round | 31/01/1981 | FC Twente | - | Willem II | 5:1 | ||||
19. Round | 07/02/1981 | FC Utrecht | - | FC Twente | 2:2 | ||||
20. Round | 13/02/1981 | Go Ahead Eagles | - | FC Twente | 3:0 | ||||
22. Round | 06/03/1981 | FC Wageningen | - | FC Twente | 0:1 | ||||
21. Round | 18/03/1981 | FC Twente | - | Roda JC Kerkrade | 3:2 |