| 1. Round | 16/07/2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 4. Round | 30/07/2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 5. Round | 06/08/2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 16. Round | 14/10/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 20. Round | 05/11/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Round | 06/12/2021 | Newell's Old Boys II | - | Banfield II | 2:0 |
Argentina