| 1. Round | 07/08/2021 | Sunderland AFC | - | Wigan Athletic | 2:1 | ||||
| 5. Round | 28/08/2021 | Wigan Athletic | - | Portsmouth FC | 1:0 | ||||
| 13. Round | 16/10/2021 | Bolton Wanderers | - | Wigan Athletic | 0:4 |  |
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| 12. Round | 26/10/2021 | Wigan Athletic | - | Lincoln City | 1:2 | ||||
| 16. Round | 30/10/2021 | Wigan Athletic | - | Burton Albion | 2:0 | ||||
| 19. Round | 23/11/2021 | Cambridge United | - | Wigan Athletic | 2:2 | ||||
| 22. Round | 11/12/2021 | Wigan Athletic | - | Ipswich Town | 1:1 | ||||
| 28. Round | 15/01/2022 | Doncaster Rovers | - | Wigan Athletic | 1:2 | ||||
| 17. Round | 18/01/2022 | Morecambe FC | - | Wigan Athletic | 1:2 | ||||
| 37. Round | 05/03/2022 | Wigan Athletic | - | AFC Wimbledon | 1:0 | ||||
| 38. Round | 12/03/2022 | Milton Keynes Dons | - | Wigan Athletic | 1:1 | ||||
| 24. Round | 15/03/2022 | Crewe Alexandra | - | Wigan Athletic | 0:2 | ||||
| 43. Round | 16/04/2022 | Wigan Athletic | - | Cambridge United | 1:2 | ||||
| 44. Round | 19/04/2022 | Ipswich Town | - | Wigan Athletic | 2:2 | ||||
| 45. Round | 23/04/2022 | Wigan Athletic | - | Plymouth Argyle | 1:1 | |
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| 27. Round | 26/04/2022 | Portsmouth FC | - | Wigan Athletic | 3:2 |
England