| 1. Round | 15/02/2022 | Santa Cruz | - | Deportes Temuco | 1:1 |  |
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| 6. Round | 22/03/2022 | Puerto Montt | - | Deportes Temuco | 3:0 | ||||
| 7. Round | 05/04/2022 | Deportes Temuco | - | Santiago Morning | 2:1 | ||||
| 8. Round | 12/04/2022 | Rangers | - | Deportes Temuco | 3:2 | ||||
| 11. Round | 25/04/2022 | Deportes Temuco | - | Deportes Melipilla | 1:1 | ||||
| 12. Round | 30/04/2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 13. Round | 06/05/2022 | Deportes Temuco | - | Universidad de Concepción | 1:0 | ||||
| 14. Round | 11/05/2022 | Recoleta | - | Deportes Temuco | 2:1 | ||||
| 15. Round | 17/05/2022 | Deportes Temuco | - | Cobreloa | 2:0 | ||||
| 18. Round | 02/07/2022 | Deportes Temuco | - | Santa Cruz | 1:1 | ||||
| 20. Round | 15/07/2022 | Deportes Temuco | - | Deportes Iquique | 3:2 | ||||
| 22. Round | 31/07/2022 | Fernández Vial | - | Deportes Temuco | 0:0 |  |
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| 23. Round | 07/08/2022 | Deportes Temuco | - | Puerto Montt | 0:1 | ||||
| 24. Round | 13/08/2022 | Santiago Morning | - | Deportes Temuco | 1:2 | ||||
| 19. Round | 16/08/2022 | Santiago Wanderers | - | Deportes Temuco | 3:0 | |
Chile