| 1. Round | 24/02/2025 | Los Angeles Galaxy | - | San Diego FC | 0:2 | ||||
| 2. Round | 02/03/2025 | San Diego FC | - | St. Louis City SC | 0:0 | ||||
| 3. Round | 09/03/2025 | Real Salt Lake | - | San Diego FC | 1:3 | ||||
| 4. Round | 16/03/2025 | San Diego FC | - | Columbus Crew | 1:1 |  |
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| 5. Round | 23/03/2025 | Austin FC | - | San Diego FC | 2:1 | ||||
| 6. Round | 30/03/2025 | San Diego FC | - | Los Angeles FC | 3:2 | ||||
| 7. Round | 06/04/2025 | San Diego FC | - | Seattle Sounders | 3:0 | ||||
| 8. Round | 13/04/2025 | Colorado Rapids | - | San Diego FC | 3:2 |  |
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| 9. Round | 20/04/2025 | Charlotte FC | - | San Diego FC | 3:0 | ||||
| 10. Round | 27/04/2025 | San Diego FC | - | Real Salt Lake | 1:3 | ||||
| 13. Round | 15/05/2025 | San Diego FC | - | Colorado Rapids | 2:0 | ||||
| 14. Round | 18/05/2025 | San Diego FC | - | Sporting Kansas City | 0:0 | ||||
| 16. Round | 29/05/2025 | Seattle Sounders | - | San Diego FC | 1:0 |
England