| 3. Round | 01/08/2010 | Sportivo Luqueño | - | Guaraní | 0:3 | ||||
| 4. Round | 07/08/2010 | Guaraní | - | Tacuary | 1:0 | ||||
| 5. Round | 14/08/2010 | Sport Colombia | - | Guaraní | 1:1 | ||||
| 6. Round | 22/08/2010 | Guaraní | - | Club Nacional | 0:0 |  |
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| 10. Round | 17/09/2010 | Cerro Porteño | - | Guaraní | 2:1 | |
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| 11. Round | 27/09/2010 | Guaraní | - | Club Rubio Ñu | 1:2 | |
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| 16. Round | 24/10/2010 | Guaraní | - | Sport Colombia | 3:0 | ||||
| 17. Round | 30/10/2010 | Club Nacional | - | Guaraní | 0:1 | ||||
| 20. Round | 21/11/2010 | Guaraní | - | Club Olimpia | 0:0 | ||||
| 21. Round | 28/11/2010 | Guaraní | - | Cerro Porteño | 1:2 | |
Paraguay