| 2. Round | 11/02/2012 | Club Rubio Ñu | - | Guaraní | 2:1 | ||||
| 4. Round | 25/02/2012 | Libertad | - | Guaraní | 2:2 | ||||
| 5. Round | 02/03/2012 | Guaraní | - | Tacuary | 4:0 | ||||
| 6. Round | 10/03/2012 | Guaraní | - | Sportivo Luqueño | 3:1 | ||||
| 7. Round | 18/03/2012 | Sol de América | - | Guaraní | 0:1 | ||||
| 8. Round | 24/03/2012 | Guaraní | - | Club Olimpia | 0:1 | ||||
| 14. Round | 28/04/2012 | Club Nacional | - | Guaraní | 1:1 |  |
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| 20. Round | 01/07/2012 | Guaraní | - | Cerro Porteño | 0:1 | ||||
| 21. Round | 04/07/2012 | Sportivo Carapeguá | - | Guaraní | 0:0 | |
Paraguay