| 27. Round | 23/12/2020 | Deportes Melipilla | - | Santa Cruz | 0:0 | ||||
| 26. Round | 28/12/2020 | Santa Cruz | - | Ñublense | 1:3 | ||||
| 28. Round | 30/12/2020 | Santa Cruz | - | San Luis | 1:3 |  |
|||
| 29. Round | 12/01/2021 | CD Magallanes | - | Santa Cruz | 2:0 | ||||
| 30. Round | 17/01/2021 | Santa Cruz | - | Deportes Valdivia | 3:2 |
Chile