1. Round | 25/07/2021 | MŠK Žilina | - | ŠKF Sereď | 3:0 | ||||
2. Round | 30/07/2021 | ŠKF Sereď | - | MFK Ružomberok | 2:3 | ||||
3. Round | 08/08/2021 | ŠKF Sereď | - | FC DAC 1904 | 1:0 | ||||
4. Round | 14/08/2021 | FK Pohronie | - | ŠKF Sereď | 1:1 | ||||
6. Round | 28/08/2021 | AS Trenčín | - | ŠKF Sereď | 0:0 | ||||
7. Round | 11/09/2021 | ŠKF Sereď | - | Tatran Liptovský Mikuláš | 2:0 | ||||
8. Round | 17/09/2021 | Spartak Trnava | - | ŠKF Sereď | 2:0 | ||||
10. Round | 02/10/2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
13. Round | 30/10/2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 | ||||
19. Round | 18/12/2021 | ŠKF Sereď | - | Spartak Trnava | 0:1 | ||||
20. Round | 11/02/2022 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:1 |