| 1. Round | 13/03/2022 | New Mexico United | - | Las Vegas Lights FC | 2:0 | ||||
| 1. Round | 20/03/2022 | Las Vegas Lights FC | - | Phoenix Rising | 2:1 | ||||
| 1. Round | 24/03/2022 | El Paso Locomotive | - | Las Vegas Lights FC | 4:5 | ||||
| 2. Round | 17/04/2022 | Las Vegas Lights FC | - | Pittsburgh Riverhounds | 1:0 | ||||
| 2. Round | 24/04/2022 | Las Vegas Lights FC | - | Los Angeles Galaxy II | 1:1 | ||||
| 3. Round | 01/05/2022 | Sacramento Republic | - | Las Vegas Lights FC | 1:1 |  |
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| 3. Round | 08/05/2022 | Monterey Bay FC | - | Las Vegas Lights FC | 1:0 | ||||
| 3. Round | 28/05/2022 | Las Vegas Lights FC | - | El Paso Locomotive | 0:1 | ||||
| 5. Round | 28/07/2022 | Las Vegas Lights FC | - | San Antonio FC | 0:2 | ||||
| 5. Round | 31/07/2022 | Atlanta United II | - | Las Vegas Lights FC | 1:1 | ||||
| 6. Round | 07/08/2022 | Phoenix Rising | - | Las Vegas Lights FC | 0:0 | ||||
| 6. Round | 28/08/2022 | Las Vegas Lights FC | - | Rio Grande Valley FC | 0:5 | ||||
| 7. Round | 04/09/2022 | Tampa Bay Rowdies | - | Las Vegas Lights FC | 6:1 |
USA