| 1. Round | 24/07/2021 | FK Jablonec | - | Baník Ostrava | 1:0 | ||||
| 2. Round | 31/07/2021 | FK Mladá Boleslav | - | FK Jablonec | 3:0 | ||||
| 4. Round | 15/08/2021 | FK Teplice | - | FK Jablonec | 1:0 | ||||
| 5. Round | 22/08/2021 | FK Jablonec | - | 1. FC Slovácko | 1:1 | ||||
| 10. Round | 03/10/2021 | FC Hradec Králové | - | FK Jablonec | 2:2 | ||||
| 12. Round | 24/10/2021 | Viktoria Plzeň | - | FK Jablonec | 5:0 | ||||
| 13. Round | 31/10/2021 | FK Jablonec | - | FK Pardubice | 1:1 | ||||
| 14. Round | 07/11/2021 | FC Fastav Zlín | - | FK Jablonec | 0:0 | ||||
| 15. Round | 21/11/2021 | Slavia Praha | - | FK Jablonec | 5:0 | ||||
| 16. Round | 28/11/2021 | FK Jablonec | - | FK Mladá Boleslav | 0:1 | ||||
| 18. Round | 12/12/2021 | FK Jablonec | - | FK Teplice | 0:2 | ||||
| 19. Round | 18/12/2021 | 1. FC Slovácko | - | FK Jablonec | 2:1 | ||||
| 24. Round | 06/03/2022 | FK Jablonec | - | FC Hradec Králové | 1:1 | ||||
| 22. Round | 09/03/2022 | FK Jablonec | - | AC Sparta Praha | 1:1 | ||||
| 25. Round | 13/03/2022 | Dynamo České Budějovice | - | FK Jablonec | 2:0 |
Czech Republic