| 11. Round | 02/06/2021 | Guayaquil SC | - | Independiente Juniors | 1:2 | ||||
| 12. Round | 06/06/2021 | Guayaquil SC | - | Gualaceo SC | 1:1 | ||||
| 17. Round | 23/06/2021 | Chacaritas FC | - | Guayaquil SC | 2:3 | ||||
| 18. Round | 27/06/2021 | Guayaquil SC | - | Liga de Portoviejo | 2:1 | ||||
| 19. Round | 04/07/2021 | Atlético Porteño | - | Guayaquil SC | 4:1 | ||||
| 21. Round | 11/07/2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
| 22. Round | 16/07/2021 | Independiente Juniors | - | Guayaquil SC | 1:2 | ||||
| 23. Round | 18/07/2021 | Guayaquil SC | - | Cumbayá | 1:2 |  |
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| 25. Round | 29/07/2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | ||||
| 31. Round | 09/09/2021 | Cumbayá | - | Guayaquil SC | 1:0 | ||||
| 33. Round | 22/09/2021 | Chacaritas FC | - | Guayaquil SC | 4:1 | ||||
| 35. Round | 06/10/2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 | ||||
| 36. Round | 13/10/2021 | Guayaquil SC | - | Atlético Porteño | 4:3 |
Ecuador