| 1. Round | 17/09/2000 | AEK Athen | - | Iraklis Saloniki | 2:0 | ||||
| 2. Round | 23/09/2000 | Athinaikos | - | AEK Athen | 0:3 |  |
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| 8. Round | 26/11/2000 | AEK Athen | - | PAS Giannina | 4:2 |  |
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| 12. Round | 02/01/2001 | AEK Athen | - | Paniliakos Pyrgos | 2:1 | ||||
| 14. Round | 13/01/2001 | PAOK Saloniki | - | AEK Athen | 2:1 | |
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| 15. Round | 20/01/2001 | AEK Athen | - | Skoda Xanthi | 2:0 | ||||
| 16. Round | 27/01/2001 | Iraklis Saloniki | - | AEK Athen | 1:2 | |
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| 18. Round | 10/02/2001 | Ethnikos Asteras | - | AEK Athen | 0:3 | ||||
| 19. Round | 17/02/2001 | AEK Athen | - | Ionikos Nikea | 2:0 | ||||
| 20. Round | 25/02/2001 | AEK Athen | - | Olympiakos Piraeus | 1:2 | ||||
| 21. Round | 04/03/2001 | Panachaiki GE | - | AEK Athen | 1:0 | ||||
| 22. Round | 11/03/2001 | AEK Athen | - | PS Kalamata | 3:0 | ||||
| 23. Round | 18/03/2001 | PAS Giannina | - | AEK Athen | 2:2 | ||||
| 24. Round | 31/03/2001 | AEK Athen | - | Panionios GSS | 5:1 | ||||
| 25. Round | 06/04/2001 | Aris Saloniki | - | AEK Athen | 0:3 | ||||
| 26. Round | 21/04/2001 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
| 27. Round | 28/04/2001 | Paniliakos Pyrgos | - | AEK Athen | 0:3 | ||||
| 28. Round | 06/05/2001 | Panathinaikos | - | AEK Athen | 0:1 | |
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| 30. Round | 25/05/2001 | Skoda Xanthi | - | AEK Athen | 0:1 |
Greece