| 1. Round | 06/08/2021 | Telstar | - | FC Emmen | 1:1 | ||||
| 2. Round | 13/08/2021 | NAC Breda | - | Telstar | 2:2 | ||||
| 3. Round | 20/08/2021 | Telstar | - | Roda JC Kerkrade | 3:4 | ||||
| 4. Round | 27/08/2021 | FC Utrecht (J) | - | Telstar | 3:0 | ||||
| 5. Round | 05/09/2021 | MVV | - | Telstar | 3:0 | ||||
| 11. Round | 15/10/2021 | Telstar | - | FC Volendam | 1:5 | ||||
| 10. Round | 18/10/2021 | Jong PSV | - | Telstar | 2:3 | ||||
| 12. Round | 22/10/2021 | Telstar | - | Helmond Sport | 2:2 | ||||
| 13. Round | 01/11/2021 | Jong Ajax | - | Telstar | 3:0 | ||||
| 14. Round | 06/11/2021 | Telstar | - | SBV Excelsior | 2:5 |  |
|||
| 15. Round | 14/11/2021 | De Graafschap | - | Telstar | 1:1 | ||||
| 35. Round | 15/04/2022 | VVV-Venlo | - | Telstar | 3:2 | ||||
| 38. Round | 06/05/2022 | Roda JC Kerkrade | - | Telstar | 4:3 |
Netherlands