| 1. Round | 01/07/2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 0:2 | ||||
| 2. Round | 08/07/2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 6. Round | 30/07/2022 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:3 | ||||
| 8. Round | 12/08/2022 | Club Tijuana [U20] | - | Puebla FC [U20] | 3:4 |  |
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| 10. Round | 20/08/2022 | Atlas Guadalajara [U20] | - | Puebla FC [U20] | 4:0 | ||||
| 11. Round | 26/08/2022 | Puebla FC [U20] | - | FC Juárez [U20] | 2:1 | ||||
| 13. Round | 07/09/2022 | Puebla FC [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 9. Round | 13/09/2022 | Puebla FC [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 15. Round | 16/09/2022 | Puebla FC [U20] | - | UANL Tigres [U20] | 1:1 | ||||
| 5. Round | 22/09/2022 | CF Monterrey [U20] | - | Puebla FC [U20] | 3:3 | ||||
| 17. Round | 30/09/2022 | Puebla FC [U20] | - | CF América [U20] | 1:1 |
Mexico