| 1. Round | 15/01/2022 | Mazorqueros | - | Colima FC | 3:2 |  |
|||
| 2. Round | 22/01/2022 | Leones Negros II | - | Mazorqueros | 0:1 | |
|||
| 3. Round | 29/01/2022 | Mazorqueros | - | Coras de Nayarit | 1:1 |  |
|||
| 4. Round | 05/02/2022 | Mineros de Fresnillo FC | - | Mazorqueros | 1:3 | ||||
| 5. Round | 12/02/2022 | Mazorqueros | - | Tuzos de la UAZ | 4:0 | |
|||
| 7. Round | 28/02/2022 | Mazorqueros | - | Cimarrones de Sonora II | 2:1 | ||||
| 8. Round | 05/03/2022 | Saltillo FC | - | Mazorqueros | 1:5 | |
|||
| 9. Round | 12/03/2022 | Mazorqueros | - | Tritones Vallarta | 1:0 | ||||
| 10. Round | 19/03/2022 | Catedráticos Elite | - | Mazorqueros | 0:2 | |
|||
| 11. Round | 26/03/2022 | Mazorqueros | - | Gavilanes de Matamoros | 0:0 | ||||
| 13. Round | 09/04/2022 | Tecos Fútbol Club | - | Mazorqueros | 2:2 | |
|
Mexico