| 3. Round | 19/01/2019 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 7. Round | 16/02/2019 | Cruz Azul | - | Santos Laguna | 1:2 | ||||
| 8. Round | 25/02/2019 | Santos Laguna | - | Deportivo Toluca | 4:0 | ||||
| 12. Round | 30/03/2019 | Atlas Guadalajara | - | Santos Laguna | 1:0 | ||||
| 15. Round | 22/04/2019 | Santos Laguna | - | Gallos Blancos | 2:1 | ||||
| 16. Round | 28/04/2019 | CF América | - | Santos Laguna | 1:0 | ||||
| 17. Round | 06/05/2019 | Santos Laguna | - | Pumas UNAM | 5:2 |
Mexico
Italy