| 3. Round | 23/01/2011 | Santos Laguna | - | CF Pachuca | 1:1 |  |
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| 4. Round | 29/01/2011 | Jaguares Chiapas | - | Santos Laguna | 1:2 | |
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| 5. Round | 06/02/2011 | Santos Laguna | - | UANL Tigres | 0:2 | |
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| 6. Round | 13/02/2011 | Atlas Guadalajara | - | Santos Laguna | 1:2 | |
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| 7. Round | 20/02/2011 | Santos Laguna | - | Gallos Blancos (old) | 0:2 | ||||
| 8. Round | 26/02/2011 | Club Necaxa | - | Santos Laguna | 1:0 | |
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| 10. Round | 13/03/2011 | Deportivo Toluca | - | Santos Laguna | 3:1 | |
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| 12. Round | 03/04/2011 | Santos Laguna | - | Cruz Azul | 3:0 |
Mexico