| 1. Round | 11/07/2021 | Metallurg Lipetsk | - | FK Tom Tomsk | 3:2 | ||||
| 2. Round | 17/07/2021 | FK Orenburg | - | Metallurg Lipetsk | 4:0 | ||||
| 3. Round | 25/07/2021 | Metallurg Lipetsk | - | Akron Tolyatti | 2:2 | ||||
| 5. Round | 08/08/2021 | Metallurg Lipetsk | - | Rotor Volgograd | 0:1 | ||||
| 6. Round | 14/08/2021 | FK Kamaz | - | Metallurg Lipetsk | 3:0 | ||||
| 14. Round | 29/09/2021 | Olimp-Dolgoprudny | - | Metallurg Lipetsk | 1:0 | ||||
| 16. Round | 09/10/2021 | Volgar Astrakhan | - | Metallurg Lipetsk | 0:2 | ||||
| 17. Round | 13/10/2021 | Metallurg Lipetsk | - | Veles Moskva | 1:0 | ||||
| 18. Round | 17/10/2021 | Metallurg Lipetsk | - | Baltika Kaliningrad | 0:4 | ||||
| 19. Round | 23/10/2021 | Fakel Voronezh | - | Metallurg Lipetsk | 3:2 | ||||
| 24. Round | 21/11/2021 | Metallurg Lipetsk | - | FK Kamaz | 0:1 | ||||
| 29. Round | 26/03/2022 | Spartak Moskva 2 | - | Metallurg Lipetsk | 3:2 | ||||
| 30. Round | 02/04/2022 | Metallurg Lipetsk | - | Alania Vladikavkaz | 0:3 | ||||
| 32. Round | 10/04/2022 | Metallurg Lipetsk | - | Olimp-Dolgoprudny | 0:0 | ||||
| 33. Round | 16/04/2022 | SKA-Khabarovsk | - | Metallurg Lipetsk | 1:0 | ||||
| 36. Round | 07/05/2022 | Baltika Kaliningrad | - | Metallurg Lipetsk | 0:0 |
Russia