| 2. Round | 25/07/2021 | Olimp-Dolgoprudny 2 | - | Enisey Krasnoyarsk 2 | 1:2 |  |
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| 4. Round | 06/08/2021 | Enisey Krasnoyarsk 2 | - | FK Kazanka Moskva | 2:1 |  |
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| 5. Round | 15/08/2021 | Dinamo Moskva 2 | - | Enisey Krasnoyarsk 2 | 3:0 | ||||
| 6. Round | 21/08/2021 | Enisey Krasnoyarsk 2 | - | FK Murom | 1:1 | ||||
| 8. Round | 04/09/2021 | Enisey Krasnoyarsk 2 | - | FK Znamya Truda | 2:0 | ||||
| 9. Round | 10/09/2021 | Shinnik Yaroslavl | - | Enisey Krasnoyarsk 2 | 3:0 | ||||
| 11. Round | 21/09/2021 | FK Chertanovo | - | Enisey Krasnoyarsk 2 | 1:3 | ||||
| 12. Round | 25/09/2021 | Enisey Krasnoyarsk 2 | - | Olimp-Dolgoprudny 2 | 3:2 | ||||
| 18. Round | 25/10/2021 | FK Znamya Truda | - | Enisey Krasnoyarsk 2 | 1:1 | |
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| 19. Round | 31/10/2021 | Enisey Krasnoyarsk 2 | - | Shinnik Yaroslavl | 1:0 | |
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| 21. Round | 10/11/2021 | Enisey Krasnoyarsk 2 | - | FK Chertanovo | 3:0 | ||||
| 22. Round | 14/11/2021 | Enisey Krasnoyarsk 2 | - | Khimik Dzerzhinsk | 0:1 |
Russia