| 2. Round | 24/07/2018 | CF América [Women] | - | Deportivo Toluca [Women] | 2:1 | ||||
| 3. Round | 27/07/2018 | Cruz Azul [Women] | - | CF América [Women] | 0:3 |  |
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| 4. Round | 05/08/2018 | CF América [Women] | - | Puebla FC [Women] | 2:0 | ||||
| 5. Round | 14/08/2018 | Club Tijuana [Women] | - | CF América [Women] | 0:1 | |
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| 7. Round | 28/08/2018 | CD Veracruz [Women] | - | CF América [Women] | 0:3 | ||||
| 8. Round | 09/09/2018 | CF América [Women] | - | CF Pachuca [Women] | 0:2 | ||||
| 9. Round | 14/09/2018 | Lobos BUAP [Women] | - | CF América [Women] | 1:2 | ||||
| 14. Round | 21/10/2018 | CF América [Women] | - | Club Tijuana [Women] | 2:1 | ||||
| 15. Round | 24/10/2018 | Pumas UNAM [Women] | - | CF América [Women] | 0:2 | ||||
| 16. Round | 29/10/2018 | CF América [Women] | - | CD Veracruz [Women] | 2:0 | ||||
| 17. Round | 06/11/2018 | CF Pachuca [Women] | - | CF América [Women] | 3:2 | |
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| 18. Round | 17/11/2018 | CF América [Women] | - | Lobos BUAP [Women] | 2:1 | |
Mexico