| 1. Round | 07/11/2021 | AEK Athen II | - | PS Kalamata | 1:0 | ||||
| 2. Round | 14/11/2021 | Panathinaikos II | - | AEK Athen II | 0:2 | ||||
| 3. Round | 20/11/2021 | AEK Athen II | - | AE Karaiskakis | 2:1 | ||||
| 4. Round | 24/11/2021 | Ergotelis | - | AEK Athen II | 0:0 | ||||
| 6. Round | 04/12/2021 | Diagoras FC | - | AEK Athen II | 0:1 | ||||
| 5. Round | 22/12/2021 | AEK Athen II | - | Asteras Vlachioti | 1:0 | ||||
| 10. Round | 29/12/2021 | GS Kallithea | - | AEK Athen II | 1:0 | ||||
| 13. Round | 12/01/2022 | AEK Athen II | - | Levadiakos | 2:1 | ||||
| 19. Round | 16/02/2022 | AEK Athen II | - | Panathinaikos II | 0:1 | ||||
| 14. Round | 16/03/2022 | AS Rhodos | - | AEK Athen II | 1:0 | ||||
| 25. Round | 19/03/2022 | AEK Athen II | - | APS Zakynthos | 1:0 | ||||
| 28. Round | 02/04/2022 | AO Egaleo | - | AEK Athen II | 1:1 | ||||
| 29. Round | 06/04/2022 | AEK Athen II | - | Irodotos | 3:1 | ||||
| 30. Round | 09/04/2022 | Levadiakos | - | AEK Athen II | 2:2 | ||||
| 27. Round | 23/04/2022 | AEK Athen II | - | GS Kallithea | 0:3 |
Greece