| 1. Round | 08/08/2009 | 1. FC Nürnberg | - | FC Schalke 04 | 1:2 | ||||
| 3. Round | 21/08/2009 | 1899 Hoffenheim | - | FC Schalke 04 | 0:0 |  |
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| 5. Round | 13/09/2009 | 1. FC Köln | - | FC Schalke 04 | 1:2 | ||||
| 6. Round | 18/09/2009 | FC Schalke 04 | - | VfL Wolfsburg | 1:2 | ||||
| 7. Round | 26/09/2009 | Borussia Dortmund | - | FC Schalke 04 | 0:1 | ||||
| 8. Round | 02/10/2009 | FC Schalke 04 | - | Eintracht Frankfurt | 2:0 | ||||
| 12. Round | 07/11/2009 | Bayern München | - | FC Schalke 04 | 1:1 | ||||
| 13. Round | 21/11/2009 | FC Schalke 04 | - | Hannover 96 | 2:0 |
Greece