| 2. Round | 14/11/2021 | Panathinaikos II | - | AEK Athen II | 0:2 | ||||
| 3. Round | 20/11/2021 | PS Kalamata | - | Panathinaikos II | 1:2 | ||||
| 16. Round | 30/01/2022 | AS Rhodos | - | Panathinaikos II | 0:0 | ||||
| 17. Round | 05/02/2022 | Panathinaikos II | - | AO Episkopi | 1:2 | ||||
| 13. Round | 09/02/2022 | Panathinaikos II | - | AO Egaleo | 0:1 | ||||
| 18. Round | 12/02/2022 | Panathinaikos II | - | AE Kifisias | 1:0 | ||||
| 26. Round | 26/03/2022 | PAE Chania | - | Panathinaikos II | 2:0 | ||||
| 27. Round | 30/03/2022 | Panathinaikos II | - | APS Zakynthos | 1:1 | ||||
| 28. Round | 02/04/2022 | OFI Ierapetra | - | Panathinaikos II | 2:0 | ||||
| 29. Round | 06/04/2022 | Panathinaikos II | - | GS Kallithea | 0:0 | ||||
| 30. Round | 09/04/2022 | AO Egaleo | - | Panathinaikos II | 2:1 | ||||
| 31. Round | 13/04/2022 | Panathinaikos II | - | Irodotos | 1:2 |
Greece