| 1. Round | 14/08/2021 | VfL Wolfsburg | - | VfL Bochum | 1:0 | ||||
| 2. Round | 21/08/2021 | VfL Bochum | - | 1. FSV Mainz 05 | 2:0 | ||||
| 3. Round | 28/08/2021 | 1. FC Köln | - | VfL Bochum | 2:1 | ||||
| 4. Round | 12/09/2021 | VfL Bochum | - | Hertha BSC | 1:3 | ||||
| 5. Round | 18/09/2021 | Bayern München | - | VfL Bochum | 7:0 | ||||
| 8. Round | 16/10/2021 | SpVgg Greuther Fürth | - | VfL Bochum | 0:1 |  |
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| 9. Round | 24/10/2021 | VfL Bochum | - | Eintracht Frankfurt | 2:0 | ||||
| 10. Round | 31/10/2021 | Bor. Mönchengladbach | - | VfL Bochum | 2:1 | ||||
| 11. Round | 06/11/2021 | VfL Bochum | - | 1899 Hoffenheim | 2:0 | ||||
| 12. Round | 20/11/2021 | Bayer Leverkusen | - | VfL Bochum | 1:0 | ||||
| 13. Round | 27/11/2021 | VfL Bochum | - | SC Freiburg | 2:1 | ||||
| 14. Round | 04/12/2021 | FC Augsburg | - | VfL Bochum | 2:3 | ||||
| 16. Round | 14/12/2021 | Arminia Bielefeld | - | VfL Bochum | 2:0 |
Greece