| 2. Round | 23/03/2022 | Atlético Santo Domingo | - | Independiente Juniors | 0:1 |  |
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| 3. Round | 27/03/2022 | Imbabura | - | Atlético Santo Domingo | 2:0 | ||||
| 4. Round | 31/03/2022 | Atlético Santo Domingo | - | Manta | 2:0 | ||||
| 5. Round | 06/04/2022 | Búhos ULVR | - | Atlético Santo Domingo | 1:0 |  |
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| 8. Round | 27/04/2022 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | |
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| 9. Round | 05/05/2022 | Atlético Santo Domingo | - | Olmedo | 1:2 | ||||
| 10. Round | 13/05/2022 | Independiente Juniors | - | Atlético Santo Domingo | 1:0 |
Ecuador