| 3. Round | 29/01/2022 | Gavilanes de Matamoros | - | Mineros de Fresnillo FC | 1:0 |  |
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| 4. Round | 05/02/2022 | Tuzos de la UAZ | - | Gavilanes de Matamoros | 1:1 |  |
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| 5. Round | 12/02/2022 | Gavilanes de Matamoros | - | Alacranes de Durango | 1:1 | ||||
| 6. Round | 18/02/2022 | Cimarrones de Sonora II | - | Gavilanes de Matamoros | 0:0 | ||||
| 7. Round | 26/02/2022 | Gavilanes de Matamoros | - | Saltillo FC | 1:2 | ||||
| 8. Round | 05/03/2022 | Tritones Vallarta | - | Gavilanes de Matamoros | 1:0 | ||||
| 9. Round | 14/03/2022 | Gavilanes de Matamoros | - | Catedráticos Elite | 3:0 | ||||
| 10. Round | 19/03/2022 | Correcaminos UAT II | - | Gavilanes de Matamoros | 0:3 | |
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| 11. Round | 26/03/2022 | Mazorqueros | - | Gavilanes de Matamoros | 0:0 | ||||
| 2. Round | 30/03/2022 | Coras de Nayarit | - | Gavilanes de Matamoros | 1:1 |  |
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| 12. Round | 02/04/2022 | Gavilanes de Matamoros | - | Tecos Fútbol Club | 1:1 | ||||
| 1. Round | 07/04/2022 | Gavilanes de Matamoros | - | Leones Negros II | 2:2 | |
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| 13. Round | 09/04/2022 | Colima FC | - | Gavilanes de Matamoros | 0:0 |
Mexico