| 2. Round | 06/02/2010 | Libertad | - | Club Rubio Ñu | 2:1 | ||||
| 3. Round | 12/02/2010 | Tacuary | - | Libertad | 0:4 |  |
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| 5. Round | 21/02/2010 | Sportivo Trinidense | - | Libertad | 1:1 | ||||
| 6. Round | 01/03/2010 | Libertad | - | Sport Colombia | 3:0 | ||||
| 7. Round | 06/03/2010 | 3 de Febrero | - | Libertad | 0:0 | ||||
| 4. Round | 10/03/2010 | Libertad | - | Sportivo Luqueño | 0:1 | ||||
| 8. Round | 14/03/2010 | Libertad | - | Club Nacional | 0:0 |  |
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| 10. Round | 20/03/2010 | Libertad | - | Club Olimpia | 0:0 | ||||
| 11. Round | 26/03/2010 | Sol de América | - | Libertad | 1:4 | ||||
| 12. Round | 03/04/2010 | Libertad | - | Guaraní | 2:1 | ||||
| 13. Round | 10/04/2010 | Club Rubio Ñu | - | Libertad | 2:1 | ||||
| 15. Round | 18/04/2010 | Sportivo Luqueño | - | Libertad | 1:2 | ||||
| 14. Round | 22/04/2010 | Libertad | - | Tacuary | 0:0 | ||||
| 9. Round | 16/05/2010 | Cerro Porteño | - | Libertad | 0:2 | ||||
| 21. Round | 22/05/2010 | Club Olimpia | - | Libertad | 0:2 | ||||
| 20. Round | 26/05/2010 | Libertad | - | Cerro Porteño | 3:0 | |
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| 22. Round | 29/05/2010 | Libertad | - | Sol de América | 3:4 | ||||
| 19. Round | 01/06/2010 | Club Nacional | - | Libertad | 1:0 |
Paraguay