| 1. Round | 18/07/2018 | Club Nacional | - | Club Olimpia | 1:2 |  |
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| 5. Round | 11/08/2018 | Club Nacional | - | Deportivo Santaní | 3:1 | |
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| 6. Round | 21/08/2018 | Libertad | - | Club Nacional | 1:0 | ||||
| 7. Round | 25/08/2018 | Club Nacional | - | Sportivo Luqueño | 3:1 | |
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| 8. Round | 01/09/2018 | Sol de América | - | Club Nacional | 1:1 | ||||
| 11. Round | 23/09/2018 | Club Nacional | - | Cerro Porteño | 0:3 | ||||
| 14. Round | 14/10/2018 | General Díaz | - | Club Nacional | 1:2 | ||||
| 15. Round | 21/10/2018 | Club Nacional | - | Guaraní | 0:0 | ||||
| 16. Round | 29/10/2018 | Deportivo Santaní | - | Club Nacional | 3:0 | ||||
| 17. Round | 04/11/2018 | Club Nacional | - | Libertad | 1:2 | |
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| 18. Round | 12/11/2018 | Sportivo Luqueño | - | Club Nacional | 1:1 | ||||
| 19. Round | 18/11/2018 | Club Nacional | - | Sol de América | 0:0 | |
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| 22. Round | 06/12/2018 | Cerro Porteño | - | Club Nacional | 1:1 |
Paraguay
Spain