| 13. Round | 27/11/2020 | Real Santa Cruz | - | Club Aurora | 4:2 | ||||
| 14. Round | 30/11/2020 | Real Santa Cruz | - | Blooming | 0:2 | ||||
| 15. Round | 02/12/2020 | The Strongest | - | Real Santa Cruz | 4:2 | ||||
| 16. Round | 07/12/2020 | Club San José | - | Real Santa Cruz | 4:1 | ||||
| 17. Round | 09/12/2020 | Real Santa Cruz | - | Real Potosí | 3:1 | ||||
| 18. Round | 12/12/2020 | Real Santa Cruz | - | Always Ready | 0:3 | ||||
| 19. Round | 14/12/2020 | Real Santa Cruz | - | Jorge Wilstermann | 1:3 |  |
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| 20. Round | 16/12/2020 | Oriente Petrolero | - | Real Santa Cruz | 3:2 | ||||
| 21. Round | 19/12/2020 | Real Santa Cruz | - | Atlético Palmaflor | 2:1 | ||||
| 22. Round | 22/12/2020 | Bolívar | - | Real Santa Cruz | 4:0 | ||||
| 23. Round | 24/12/2020 | Real Santa Cruz | - | Royal Pari | 2:4 | ||||
| 24. Round | 27/12/2020 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 25. Round | 29/12/2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | |
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| 26. Round | 31/12/2020 | Club Aurora | - | Real Santa Cruz | 1:1 | |
Bolivia