| 2. Round | 13/03/2021 | Jorge Wilstermann | - | Nacional Potosí | 1:2 |  |
|||
| 6. Round | 02/05/2021 | Real Potosí | - | Nacional Potosí | 1:2 | ||||
| 7. Round | 09/05/2021 | Nacional Potosí | - | CD Guabirá | 2:1 | |
|||
| 11. Round | 24/07/2021 | Nacional Potosí | - | Real Tomayapo | 0:0 | ||||
| 18. Round | 14/09/2021 | Atlético Palmaflor | - | Nacional Potosí | 0:0 | ||||
| 19. Round | 19/09/2021 | Nacional Potosí | - | Always Ready | 0:2 | ||||
| 20. Round | 23/09/2021 | Royal Pari | - | Nacional Potosí | 2:0 | ||||
| 21. Round | 26/09/2021 | Nacional Potosí | - | Real Potosí | 4:2 | ||||
| 22. Round | 18/10/2021 | CD Guabirá | - | Nacional Potosí | 3:2 | ||||
| 23. Round | 24/10/2021 | Nacional Potosí | - | Blooming | 4:0 | ||||
| 24. Round | 28/10/2021 | Bolívar | - | Nacional Potosí | 4:2 | ||||
| 25. Round | 31/10/2021 | Nacional Potosí | - | Club Aurora | 0:0 | ||||
| 27. Round | 26/11/2021 | Nacional Potosí | - | Club San José | 7:1 |  |
|||
| 30. Round | 10/12/2021 | Nacional Potosí | - | Oriente Petrolero | 1:0 |
Bolivia