| 1. Round | 13/07/2019 | Sol de América | - | Club Nacional | 2:1 | ||||
| 2. Round | 19/07/2019 | Club Nacional | - | Club Olimpia | 1:3 | ||||
| 3. Round | 27/07/2019 | General Díaz | - | Club Nacional | 1:1 | ||||
| 4. Round | 03/08/2019 | River Plate | - | Club Nacional | 0:1 | ||||
| 5. Round | 09/08/2019 | Club Nacional | - | Libertad | 1:0 | ||||
| 6. Round | 16/08/2019 | Sportivo Luqueño | - | Club Nacional | 1:1 | ||||
| 7. Round | 27/08/2019 | Club Nacional | - | Cerro Porteño | 1:1 |  |
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| 8. Round | 31/08/2019 | Deportivo Santaní | - | Club Nacional | 3:1 | ||||
| 9. Round | 15/09/2019 | Club Nacional | - | Deportivo Capiatá | 3:0 |  |
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| 10. Round | 21/09/2019 | San Lorenzo | - | Club Nacional | 0:3 | ||||
| 11. Round | 25/09/2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 12. Round | 29/09/2019 | Club Nacional | - | Sol de América | 0:0 | ||||
| 13. Round | 06/10/2019 | Club Olimpia | - | Club Nacional | 3:0 | ||||
| 17. Round | 23/11/2019 | Club Nacional | - | Sportivo Luqueño | 1:1 | ||||
| 19. Round | 26/11/2019 | Club Nacional | - | Deportivo Santaní | 4:0 | ||||
| 20. Round | 02/12/2019 | Deportivo Capiatá | - | Club Nacional | 0:0 | ||||
| 21. Round | 09/12/2019 | Club Nacional | - | San Lorenzo | 4:2 | |
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| 22. Round | 15/12/2019 | Guaraní | - | Club Nacional | 0:5 | |
Paraguay