| 1. Round | 26/07/2021 | Club Tijuana | - | UANL Tigres | 1:2 | ||||
| 2. Round | 31/07/2021 | Club León | - | Club Tijuana | 2:1 | ||||
| 3. Round | 07/08/2021 | Club Tijuana | - | Deportivo Toluca | 0:2 |  |
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| 4. Round | 14/08/2021 | FC Juárez | - | Club Tijuana | 1:1 | ||||
| 5. Round | 18/08/2021 | Club Tijuana | - | Puebla FC | 1:1 | ||||
| 6. Round | 22/08/2021 | CF América | - | Club Tijuana | 2:0 | ||||
| 10. Round | 25/09/2021 | Club Tijuana | - | Mazatlán FC | 0:0 | ||||
| 11. Round | 28/09/2021 | Club Necaxa | - | Club Tijuana | 3:0 | ||||
| 12. Round | 04/10/2021 | Club Tijuana | - | Cruz Azul | 0:1 | |
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| 13. Round | 15/10/2021 | Gallos Blancos | - | Club Tijuana | 1:1 | ||||
| 14. Round | 21/10/2021 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | |
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| 15. Round | 24/10/2021 | Pumas UNAM | - | Club Tijuana | 3:1 | ||||
| 16. Round | 29/10/2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
| 17. Round | 07/11/2021 | Club Tijuana | - | CF Pachuca | 3:2 |
Mexico