| 3. Round | 31/01/2010 | Club San Luis | - | Monarcas Morelia | 0:2 | ||||
| 5. Round | 14/02/2010 | Club San Luis | - | Indios Juárez | 1:1 |  |
|||
| 6. Round | 18/02/2010 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 7. Round | 21/02/2010 | Club San Luis | - | Atlas Guadalajara | 3:1 | ||||
| 8. Round | 28/02/2010 | Deportivo Guadalajara | - | Club San Luis | 2:0 | ||||
| 9. Round | 07/03/2010 | Club San Luis | - | Cruz Azul | 1:2 | ||||
| 17. Round | 25/04/2010 | Club San Luis | - | Gallos Blancos (old) | 3:0 |
Mexico