| 1. Round | 25/07/2010 | Club San Luis | - | CF Monterrey | 1:1 | ||||
| 2. Round | 01/08/2010 | Puebla FC | - | Club San Luis | 2:1 | ||||
| 3. Round | 08/08/2010 | Club San Luis | - | Deportivo Guadalajara | 0:1 | ||||
| 9. Round | 25/09/2010 | Jaguares Chiapas | - | Club San Luis | 2:1 | ||||
| 12. Round | 16/10/2010 | Club San Luis | - | Gallos Blancos (old) | 3:2 | ||||
| 14. Round | 29/10/2010 | Club San Luis | - | CF América | 1:2 |  |
|||
| 16. Round | 06/11/2010 | Club San Luis | - | Santos Laguna | 1:1 | ||||
| 17. Round | 13/11/2010 | Cruz Azul | - | Club San Luis | 1:0 |
Mexico