| 2. Round | 29/01/2025 | Club Nacional | - | Libertad | 0:3 | ||||
| 5. Round | 15/02/2025 | Club Nacional | - | Guaraní | 1:2 | ||||
| 6. Round | 22/02/2025 | Sportivo Ameliano | - | Club Nacional | 2:1 | ||||
| 7. Round | 01/03/2025 | Club Nacional | - | Atlético Tembetary | 1:0 | ||||
| 8. Round | 10/03/2025 | Sportivo Luqueño | - | Club Nacional | 2:1 | ||||
| 12. Round | 07/04/2025 | Club Nacional | - | 2 de Mayo | 1:0 | ||||
| 14. Round | 16/04/2025 | Club Nacional | - | Cerro Porteño | 1:3 |
Paraguay