| 1. Round | 17/07/2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 2. Round | 20/07/2022 | Libertad | - | Club Olimpia | 4:2 |  |
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| 3. Round | 24/07/2022 | Club Olimpia | - | Guaireña FC | 2:1 |  |
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| 4. Round | 31/07/2022 | Tacuary | - | Club Olimpia | 2:1 | ||||
| 7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
| 12. Round | 20/09/2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 14. Round | 02/10/2022 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 15. Round | 06/10/2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Round | 09/10/2022 | Sportivo Ameliano | - | Club Olimpia | 0:2 | ||||
| 13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 | |
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| 17. Round | 16/10/2022 | Cerro Porteño | - | Club Olimpia | 1:2 | ||||
| 18. Round | 22/10/2022 | Club Olimpia | - | General Caballero DJLM | 2:1 |  |
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| 21. Round | 08/11/2022 | Sol de América | - | Club Olimpia | 0:2 | ||||
| 22. Round | 12/11/2022 | Club Olimpia | - | Club Nacional | 1:1 |
Argentina