| 6. Round | 25/08/2021 | Akademiya Konopleva [Youth B] | - | FK Rostov [Youth B] | 1:7 | ||||
| 7. Round | 11/09/2021 | SShOR Zenit [Youth B] | - | FK Rostov [Youth B] | 1:4 |  |
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| 12. Round | 13/11/2021 | FK Rostov [Youth B] | - | Spartak Moskva [Youth B] | 1:0 | ||||
| 15. Round | 20/11/2021 | CSKA Moskva [Youth B] | - | FK Rostov [Youth B] | 3:0 | ||||
| 16. Round | 27/11/2021 | FK Rostov [Youth B] | - | Lokomotiv Moskva [Youth B] | 1:5 | ||||
| 20. Round | 09/04/2022 | FK Rostov [Youth B] | - | SShOR Zenit [Youth B] | 3:0 | ||||
| 23. Round | 01/05/2022 | FK Rostov [Youth B] | - | Zenit St. Petersburg [Youth B] | 2:1 | ||||
| 24. Round | 07/05/2022 | FK Krasnodar [Youth B] | - | FK Rostov [Youth B] | 1:1 | |
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| 25. Round | 14/05/2022 | FK Rostov [Youth B] | - | Uor-5 Egorievsk [Youth B] | 0:2 | ||||
| 26. Round | 21/05/2022 | Spartak Moskva [Youth B] | - | FK Rostov [Youth B] | 0:3 |
Russia