| 1. Round | 06/08/2021 | LB Châteauroux | - | SO Cholet | 2:0 | ||||
| 5. Round | 03/09/2021 | Stade Lavallois | - | SO Cholet | 2:1 |  |
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| 6. Round | 10/09/2021 | SO Cholet | - | US Concarneau | 4:2 | ||||
| 8. Round | 24/09/2021 | SO Cholet | - | FC Chambly | 2:0 | ||||
| 10. Round | 08/10/2021 | SO Cholet | - | US Orléans | 3:1 | ||||
| 11. Round | 22/10/2021 | FC Annecy | - | SO Cholet | 3:0 | ||||
| 13. Round | 05/11/2021 | FC Bastia-Borgo | - | SO Cholet | 1:2 |
France