| 16. Round | 05/02/2022 | F91 Dudelange | - | Progrès Niedercorn | 1:2 |  |
|||
| 17. Round | 12/02/2022 | Progrès Niedercorn | - | Victoria Rosport | 3:3 | ||||
| 18. Round | 20/02/2022 | Jeunesse Esch | - | Progrès Niedercorn | 0:1 | ||||
| 19. Round | 27/02/2022 | Progrès Niedercorn | - | CS FOLA Esch | 4:1 | ||||
| 20. Round | 06/03/2022 | US Hostert | - | Progrès Niedercorn | 0:4 | ||||
| 21. Round | 12/03/2022 | Progrès Niedercorn | - | UNA Strassen | 0:2 | ||||
| 22. Round | 19/03/2022 | RFCU Luxemburg | - | Progrès Niedercorn | 3:3 | |
|||
| 23. Round | 02/04/2022 | Progrès Niedercorn | - | Swift Hesperange | 2:2 | ||||
| 24. Round | 10/04/2022 | Union Titus Pétange | - | Progrès Niedercorn | 0:0 | ||||
| 25. Round | 16/04/2022 | Progrès Niedercorn | - | FC Rodange 91 | 1:2 |  |
|||
| 26. Round | 24/04/2022 | US Mondorf | - | Progrès Niedercorn | 2:1 | ||||
| 27. Round | 01/05/2022 | Progrès Niedercorn | - | RM Hamm Benfica | 5:1 | ||||
| 28. Round | 07/05/2022 | Etzella Ettelbruck | - | Progrès Niedercorn | 1:1 | |
|||
| 29. Round | 15/05/2022 | Progrès Niedercorn | - | FC Wiltz 71 | 2:1 |
France