| 1. Round | 10/07/2010 | Tavriya Simferopol (1958-2014) | - | Metalist Kharkiv | 0:1 | ||||
| 2. Round | 17/07/2010 | PFK Sevastopol | - | Metalist Kharkiv | 0:0 | ||||
| 5. Round | 07/08/2010 | Metalist Kharkiv | - | Vorskla Poltava | 2:3 | ||||
| 6. Round | 14/08/2010 | Dnipro Dnipropetrovsk | - | Metalist Kharkiv | 0:1 | ||||
| 7. Round | 22/08/2010 | Metalist Kharkiv | - | FK Krivbas (old) | 3:4 | ||||
| 11. Round | 25/09/2010 | Metalist Kharkiv | - | Shakhtar Donetsk | 1:2 | ||||
| 12. Round | 03/10/2010 | Karpaty Lviv | - | Metalist Kharkiv | 0:1 | ||||
| 13. Round | 16/10/2010 | Metalist Kharkiv | - | Volyn Lutsk | 3:1 | ||||
| 14. Round | 24/10/2010 | FK Illichivets | - | Metalist Kharkiv | 1:4 | ||||
| 15. Round | 30/10/2010 | Metalist Kharkiv | - | FK Obolon | 2:1 | ||||
| 16. Round | 07/11/2010 | Metalist Kharkiv | - | Tavriya Simferopol (1958-2014) | 2:3 | ||||
| 17. Round | 13/11/2010 | Metalist Kharkiv | - | PFK Sevastopol | 4:0 | ||||
| 18. Round | 21/11/2010 | Dinamo Kiev | - | Metalist Kharkiv | 1:1 |  |
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| 19. Round | 27/11/2010 | Metalist Kharkiv | - | Metalurh Donetsk | 3:1 |
Moldova
Russia