| 5. Round | 21/08/2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | ||||
| 7. Round | 11/09/2021 | Rukh Lviv | - | Zorya Lugansk | 1:1 | ||||
| 15. Round | 20/11/2021 | Shakhtar Donetsk | - | Rukh Lviv | 2:0 | ||||
| 16. Round | 28/11/2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Round | 04/12/2021 | Rukh Lviv | - | Vorskla Poltava | 0:0 | ||||
| 18. Round | 11/12/2021 | NK Veres | - | Rukh Lviv | 1:1 |
Ukraine