| 6. Round | 01/02/2025 | Atlético San Luis [Women] | - | Santos Laguna [Women] | 3:0 | ||||
| 7. Round | 07/02/2025 | Santos Laguna [Women] | - | Club Tijuana [Women] | 1:3 |  |
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| 8. Round | 09/02/2025 | Deportivo Toluca [Women] | - | Santos Laguna [Women] | 2:1 | ||||
| 9. Round | 14/02/2025 | Santos Laguna [Women] | - | CF Pachuca [Women] | 1:3 |  |
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| 10. Round | 05/03/2025 | Gallos Blancos [Women] | - | Santos Laguna [Women] | 3:0 | ||||
| 11. Round | 11/03/2025 | Santos Laguna [Women] | - | Cruz Azul [Women] | 0:1 | ||||
| 12. Round | 15/03/2025 | UANL Tigres [Women] | - | Santos Laguna [Women] | 5:0 | ||||
| 13. Round | 19/03/2025 | Santos Laguna [Women] | - | CF Monterrey [Women] | 1:3 | |
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| 14. Round | 23/03/2025 | Puebla FC [Women] | - | Santos Laguna [Women] | 2:1 | ||||
| 15. Round | 29/03/2025 | Santos Laguna [Women] | - | CF América [Women] | 0:3 | ||||
| 17. Round | 18/04/2025 | Mazatlán FC [Women] | - | Santos Laguna [Women] | 1:2 |
Nigeria