| 12. Round | 30/09/2021 | FK Orenburg 2 | - | FK Novosibirsk | 0:0 | ||||
| 14. Round | 10/10/2021 | Nosta Novotroitsk | - | FK Orenburg 2 | 3:0 | ||||
| 15. Round | 17/10/2021 | FK Orenburg 2 | - | Zenit Izhevsk | 2:2 | ||||
| 17. Round | 31/10/2021 | FK Orenburg 2 | - | Nosta Novotroitsk | 0:2 | ||||
| 18. Round | 04/11/2021 | FK Amkar Perm | - | FK Orenburg 2 | 3:0 | ||||
| 19. Round | 09/11/2021 | FK Novosibirsk | - | FK Orenburg 2 | 1:0 | ||||
| 25. Round | 30/04/2022 | FK Orenburg 2 | - | Volga Ulyanovsk | 2:3 | ||||
| 27. Round | 18/05/2022 | Irtysh Omsk | - | FK Orenburg 2 | 1:1 | ||||
| 28. Round | 21/05/2022 | Dinamo Barnaul | - | FK Orenburg 2 | 3:0 | ||||
| 29. Round | 28/05/2022 | FK Orenburg 2 | - | FK Chelyabinsk | 0:3 | ||||
| 30. Round | 04/06/2022 | Torpedo Miass | - | FK Orenburg 2 | 2:1 |
Russia