| 1. Round | 08/09/2000 | Real Sociedad | - | Racing Santander | 2:2 |  |
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| 2. Round | 15/09/2000 | Racing Santander | - | Deportivo La Coruña | 0:3 | ||||
| 3. Round | 22/09/2000 | FC Barcelona | - | Racing Santander | 3:1 | ||||
| 4. Round | 29/09/2000 | Racing Santander | - | Real Madrid | 0:0 |  |
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| 7. Round | 27/10/2000 | UD Las Palmas | - | Racing Santander | 2:1 | ||||
| 8. Round | 31/10/2000 | Racing Santander | - | Villarreal CF | 3:1 | ||||
| 9. Round | 04/11/2000 | Real Zaragoza | - | Racing Santander | 2:0 | ||||
| 10. Round | 11/11/2000 | Racing Santander | - | CA Osasuna | 0:0 | ||||
| 11. Round | 18/11/2000 | RC Celta | - | Racing Santander | 1:1 | ||||
| 12. Round | 25/11/2000 | Racing Santander | - | Espanyol Barcelona | 1:2 | ||||
| 13. Round | 01/12/2000 | Rayo Vallecano | - | Racing Santander | 4:1 | ||||
| 14. Round | 09/12/2000 | Racing Santander | - | CD Alavés | 2:1 | ||||
| 15. Round | 16/12/2000 | Real Oviedo | - | Racing Santander | 1:0 | ||||
| 19. Round | 20/01/2001 | Athletic Club | - | Racing Santander | 3:1 |
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