| 1. Round | 12/09/2021 | FC Schalke 04 [Youth] | - | 1. FC Köln [Youth] | 4:1 | ||||
| 3. Round | 26/09/2021 | 1. FC Köln [Youth] | - | Fortuna Düsseldorf [Youth] | 6:1 | ||||
| 6. Round | 24/10/2021 | Wuppertaler SV [Youth] | - | 1. FC Köln [Youth] | 0:4 | ||||
| 7. Round | 30/10/2021 | 1. FC Köln [Youth] | - | Borussia Dortmund [Youth] | 0:1 | ||||
| 5. Round | 20/11/2021 | 1. FC Köln [Youth] | - | Bayer Leverkusen [Youth] | 1:1 | ||||
| 8. Round | 28/11/2021 | Viktoria Köln [Youth] | - | 1. FC Köln [Youth] | 1:5 | ||||
| 11. Round | 12/02/2022 | 1. FC Köln [Youth] | - | Preußen Münster [Youth] | 0:2 | ||||
| 12. Round | 20/02/2022 | Rot-Weiss Essen [Youth] | - | 1. FC Köln [Youth] | 1:1 | ||||
| 10. Round | 26/02/2022 | VfL Bochum [Youth] | - | 1. FC Köln [Youth] | 0:1 | ||||
| 13. Round | 05/03/2022 | 1. FC Köln [Youth] | - | Rot-Weiß Oberhausen [Youth] | 2:1 | ||||
| 14. Round | 02/04/2022 | SC Paderborn 07 [Youth] | - | 1. FC Köln [Youth] | 0:0 | ||||
| 16. Round | 23/04/2022 | MSV Duisburg [Youth] | - | 1. FC Köln [Youth] | 2:1 | ||||
| 17. Round | 30/04/2022 | 1. FC Köln [Youth] | - | Arminia Bielefeld [Youth] | 7:0 |  |
Moldova
Romania