| 4. Round | 14/08/2021 | FC Juárez | - | Club Tijuana | 1:1 | ||||
| 5. Round | 18/08/2021 | Club Tijuana | - | Puebla FC | 1:1 |  |
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| 6. Round | 22/08/2021 | CF América | - | Club Tijuana | 2:0 | |
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| 7. Round | 28/08/2021 | Club Tijuana | - | CF Monterrey | 2:2 |  |
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| 8. Round | 11/09/2021 | Club Tijuana | - | Santos Laguna | 2:1 | |
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| 9. Round | 17/09/2021 | Atlético San Luis | - | Club Tijuana | 4:1 | ||||
| 10. Round | 25/09/2021 | Club Tijuana | - | Mazatlán FC | 0:0 | ||||
| 11. Round | 28/09/2021 | Club Necaxa | - | Club Tijuana | 3:0 | ||||
| 12. Round | 04/10/2021 | Club Tijuana | - | Cruz Azul | 0:1 | ||||
| 13. Round | 15/10/2021 | Gallos Blancos | - | Club Tijuana | 1:1 | |
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| 15. Round | 24/10/2021 | Pumas UNAM | - | Club Tijuana | 3:1 | |
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| 16. Round | 29/10/2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
| 17. Round | 07/11/2021 | Club Tijuana | - | CF Pachuca | 3:2 |
Mexico