| 2. Round | 23/07/2021 | Fakel Voronezh 2 | - | FK Sakhalin | 0:2 | ||||
| 3. Round | 04/08/2021 | FK Ryazan | - | FK Sakhalin | 2:0 | ||||
| 4. Round | 08/08/2021 | Arsenal Tula 2 | - | FK Sakhalin | 3:0 | ||||
| 5. Round | 15/08/2021 | Dinamo Bryansk | - | FK Sakhalin | 2:0 | ||||
| 6. Round | 21/08/2021 | FK Kaluga | - | FK Sakhalin | 1:1 |  |
|||
| 7. Round | 02/09/2021 | FK Sakhalin | - | Zenit Penza | 0:1 | |
|||
| 9. Round | 11/09/2021 | Salyut Belgorod | - | FK Sakhalin | 0:2 | |
|||
| 12. Round | 26/09/2021 | FK Sakhalin | - | Dinamo Vladivostok | 1:5 | ||||
| 14. Round | 03/10/2021 | FK Sakhalin | - | Fakel Voronezh 2 | 1:0 | ||||
| 15. Round | 10/10/2021 | FK Sakhalin | - | FK Ryazan | 0:2 | ||||
| 18. Round | 22/10/2021 | FK Sakhalin | - | FK Kaluga | 0:1 | |
|||
| 20. Round | 03/11/2021 | Sokol Saratov | - | FK Sakhalin | 3:0 | ||||
| 11. Round | 07/11/2021 | Dinamo Vladivostok | - | FK Sakhalin | 4:0 |
Russia