| 6. Round | 17/10/2020 | FC Mynai | - | FK Mariupol | 0:1 | ||||
| 7. Round | 25/10/2020 | Inhulets Petrove | - | FK Mariupol | 1:1 | ||||
| 9. Round | 07/11/2020 | Olimpik Donetsk | - | FK Mariupol | 3:3 |  |
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| 10. Round | 20/11/2020 | Rukh Lviv | - | FK Mariupol | 0:0 | ||||
| 11. Round | 27/11/2020 | FK Lviv | - | FK Mariupol | 1:3 | ||||
| 14. Round | 14/02/2021 | FK Mariupol | - | FK Oleksandriya | 0:1 | ||||
| 15. Round | 20/02/2021 | FK Mariupol | - | Zorya Lugansk | 0:1 |  |
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| 16. Round | 27/02/2021 | FK Mariupol | - | SK Dnipro-1 | 2:2 | ||||
| 17. Round | 06/03/2021 | FK Mariupol | - | Vorskla Poltava | 0:1 |  |
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| 19. Round | 20/03/2021 | FK Mariupol | - | FC Mynai | 0:0 | |
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| 20. Round | 03/04/2021 | FK Mariupol | - | Inhulets Petrove | 4:3 | |
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| 22. Round | 18/04/2021 | FK Mariupol | - | Olimpik Donetsk | 1:1 | ||||
| 23. Round | 23/04/2021 | FK Mariupol | - | Rukh Lviv | 0:3 | ||||
| 24. Round | 02/05/2021 | FK Mariupol | - | FK Lviv | 1:2 | ||||
| 25. Round | 05/05/2021 | Dinamo Kiev | - | FK Mariupol | 0:0 | |
Ukraine